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OCR: sm on Previously, adults with panhypopituita 'full' hormone replacement therapy we recently it considered to be restored to 'normal', bu ve a has been shown that, as a group, they h marked increase in premature 'total' an have 'cardiovascular' mortality, and also ofte a, physical major abnormalities in body compositi ment performance, and quality of life. Replace ever, is therapy with GH in deficient adults, ho I been still experimental, and its role has not y accepted by all authorities. See later: . Changes in Body Composition . Characteristics of Physical Performan · Cardiovascular and Renal Effects Metabolic Effects · Psychological Effects . Side Effects of GH Therapy See also: . GH Replacement in Childhood